Endocrine Abstracts

Graves’ disease (GD) is an autoimmune and polygenic disorder. The genetic loci conferring susceptibility need to be still defined. Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene has been reported to be associated with GD in various ethnic groups. The aim of the present study was to determine whether CTLA-4 gene was associated with GD in Turkish population. We evaluated the allele distribution of the following loci: CTLA-4 exon 1 (+49 A/G) and promoter (−318 C/T) reg...